张书圣，教授，男，1966年3月生，1999年3月毕业于南京大学，获博士学位，博士生导师。研究方向为生化分析。现任《Frontiers in Chemistry》副主编、《分析化学》编委、《应用化学》编委，教育部生化分析创新团队负责人，泰山学者攀登计划特聘教授，国家杰出青年基金获得者，国家百千万人才工程“有突出贡献中青年专家，享受国务院政府特殊津贴，全国优秀教师，山东省有突出贡献的中青年专家，山东省高校首席专家。
承担的主要科研项目:
1：肿瘤标志物的光电化学传感分析(鲁政办字[2015]16号) 2014-2018 350万 张书圣
2：生化分析创新团队(教技函[2015]88号) 2016-2018 300万 张书圣
3：可控三维等离子体探针的筑建及其在单细胞成像分析中的应用（21775063） 2018-2021 65万 张书圣
4：单分子仿生界面的构建及其在成像分析中的应用研究（21535002） 2016-2019 300万 张书圣
5：集成电化学方法的宽频自适应差分石英晶体微天平的研制及其在肿瘤标志物检测中的应用（21227008） 2013-2016 310万 张书圣
6：肿瘤标志物的光电化学传感分析方法（国家杰出青年科学基金21025523） 2011-2014 200万 张书圣
7：小动物PET/CT/FMI三模态同机融合成像系统（山东省自然科学基金重大基础研究项目, ZR2017ZC0226） 2017-2019 500万 张书圣
8：生物功能化纳米载体在靶向肿瘤细胞成像及药物控释中的应用研究（山东省自然科学基金重大基础研究项目，ZR2018ZC0231） 2018-2020 100万 杨文荣，张书圣
9：肿瘤标志物的单分子检测技术研究（山东省领军人才前瞻性研究专题项目, ZR2016QZ001） 2016-2018 100万 张书圣
10：科技领军人才创新工作室 2018-2020 300万 张书圣
代表性论文:
1.Yingnan Sun, Xiaodong Chen, Yongxin Zheng, Yuhan Song, Huairong Zhang,Shusheng Zhang*
Surface-Enhanced Raman Scattering Trace-Detection Platform Based on Continuous-Rolling-Assisted Evaporation on Superhydrophobic Surfaces
ACS Appl. Nano Mater.,2020, 3, 4767-4776
2.Caixia Wang, Bo Wu, Yuting Wu, Xinyue Song,Shusheng Zhang*, Zhihong Liu*
Camouflaging Nanoparticles with Brain Metastatic Tumor Cell Membranes: A New Strategy to Traverse Blood-brain Barrier for Imaging and Therapy of Brain Tumors
Adv. Funct. Mater.,2020, 30(14), 1909369.
3.Zhongfeng Gao, Rui Liu, Jinhua Wang, Jun Dai, Weihua Huang, Mingjie Liu, Shutao Wang, Fan Xia*,Shusheng Zhang*, Lei Jiang
Manipulating the hydrophobicity of DNA as a universal strategy for visual biosensing
Nature Protocols., 2020, 15, 316~337
4.Zhen Fang, Liping Liu, Ying Wang, Dongmei Xi*,Shusheng Zhang*
Unambiguous Discrimination of Multiple Protein Biomarkers by Nanopore Sensing with Double-Stranded DNA-Based Probes
Anal. Chem.,2020, 92 (2): 1730~1737.
5.Junwei Li, Dandan Yuan, Xiangjiang Zheng, Xinyue Zhang, Xuemei Li*,Shusheng Zhang*
A triple-combination nanotechnology platform based on multifunctional RNA hydrogel for lung cancer therapy
Sci.ChinaChem., 2020, 63: 546~553
6.Lili Jiang, Yuling Yang, Yuhong Lin, Ziyi Chen, Chao Xing, Chunhua Lu*, Huanghao Yang,Shusheng Zhang*
An electrochemical sensor based on enzyme-free recycling amplification for sensitive and specific detection of miRNAs from cancer cells
Analyst, 2020, 145 (9): 3353-3358.
7.闫 涛，刘振华，宋昕玥*，张书圣*
肿瘤微环境刺激响应型上转换光动力诊疗体系的构建和发展
化学学报，2020, doi:10.6023/A20040132
8.Lanlan Chen*, Shuai Xu, Wei Li, Tianbing Ren, Lin Yuan,Shusheng Zhang*, Xiaobing Zhang*
Tumor-Acidity Activated Surface Charge Conversion of Two-Photon Fluorescent Nanoprobe for Enhanced Cellular Uptake and Targeted Imaging of Intracellular Hydrogen Peroxide
Chem. Sci.,2019, 10: 9351~9357.
9.Xinyue Song, Zihong Yue, Tongtong Hong, Zonghua Wang,Shusheng Zhang*
Sandwich-structured upconversion nanoprobes coated with thin silica layer for mitochondria-targeted cooperative photodynamic therapy for solid malignant tumors
Anal. Chem.,2019,91: 8549~8557
10.Huairong Zhang, Wanxia Gao,Yong Liu, Yingnan Sun, Yanxialei Jiang,Shusheng Zhang*
Electrochemiluminescence-Microscopy for microRNA Imaging in Single Cancer Cell Combined with Chemotherapy-Photothermal Therapy
Anal. Chem.,2019, 91: 12581~12586
11.Xiaoru Zhang, Chao Liu, Yujiao Pei, Weiling Song,Shusheng Zhang*Preparation of novel Raman probe and its application in the detection of CTCs and exosomes
ACS Appl. Mater. Interfaces,2019,32: 28671~28680.
12.Zhen Zhang, Mengting Zhu, Zichao Chen, Xiaomeng Wang, Guang Chen*,Shusheng Zhang*
Coaxial Sensing Bio-amplifier for Ultrasensitive Detections of the Mutated Circulating Tumor DNAs
Biosens. Bioelectron.,2019, 141: 111414
13.Jing Liu, Fenfen Zhai, Hong Zhou*, Wenrong Yang,Shusheng Zhang*
NanogoldFlower-inspired Nanoarchitectonics EnablesEnhanced Light-to-Heat Conversion Ability for Rapid and Targeted Chemo-Photothermal Therapy of a Tumor
Adv. Healthc. Mater.,2019, 8: 1801300
14.Hong Zhou, Jing Liu, Jing-Juan Xu*,Shusheng Zhang*, Hong-Yuan Chen
Chapter Two-Advances in DNA/RNA detection using nanotechnology
Adv. Clin. Chem.,2019, 91: 31~98
15.刘丽赏,姜耀,李雪梅*,张书圣*
石英晶体微天平在肿瘤标志物检测中的应用
中国科学-化学, 2019,49(2): 276~284
16.Hong Zhou, Jing Liu, Jing-Juan Xu*,Shusheng Zhang*, Hong-Yuan Chen
Optical Nano-Biosensing Interface via Nucleic Acid Amplification Strategy: Construction and Application
Chem. Soc. Rev.,2018, 47: 1996~2019.
17.Dongmei Xi, Zhi Li, Liping Liu, Shiyun Ai*,Shusheng Zhang*
Ultrasensitive detection of cancer cells combining enzymatic cycling amplification with an aerolysin nanopore
Anal. Chem.,2018,90(1): 1029~1034.
18.Yingnan Sun, Wenhua Song, Xiaohan Sun,Shusheng Zhang*
Inkjet-Printing Patterned Chip on Sticky Superhydrophobic Surface for High-Efficiency Single-Cell Array Trapping and Real-Time Observation of Cellular Apoptosis
ACS Appl. Mater. Interfaces,2018, 10: 31054~31060.
19.Xinyue Song, Zihong Yue, Jiayu Zhang, Zonghua Wang,Shusheng Zhang*
Multi-color upconversion nanoprobe based on dual luminescence resonance energy transfer assay for simultaneous detection and bioimaging of intracellular [Ca2+]iand pHiin living cells
Chem.-Euro. J.,2018,24: 6458~ 6463.(热点文章)
20.Mengting Zhu, Zhaomei Sun, Zhen Zhang*,Shusheng Zhang*
Ultrasensitive SERS detection of highly homologous miRNAs by generating 3D organic-nanoclusters and a functionalized chip with locked nucleic acid probes
Chem. Commun.,2018,54: 13431~13434
21.Min Gao, Lanlan Chen, Zhenhua Zhang, Xuping Sun*,Shusheng Zhang*
Interface engineering of Ni(OH)2-Ni3N nanoarray heterostructure for alkaline hydrogen evolution reaction
J. Mater. Chem. A,2018, 6: 833~836.
22.Xiaoru Zhang, Fengting Chen, Xiaojie Song, Peng He,Shusheng Zhang*Proximity Ligation Detection of Lectin Concanavalin A and Fluorescence Imaging Cancer Cells Using Carbohydrate Functionalized DNA-Silver Nanocluster Probes
Biosens. Bioelectron.,2018, 104: 27~31
23.Yuting Jiao, Mengting Zhu, Xiaomeng Wang,Zhen Zhang*,Shusheng Zhang*
Self-Assembly of Bidirectional-Signal Nanoclusters for Two miRNAs Simultaneously Monitoring in Single Cancer Cells
Part. Part. Syst. Char.,2018, 35(2): 1700330.
24.Sai Bi, Shuzhen Yue,Shusheng Zhang*
Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging and biomedicine
Chem. Soc. Rev., 2017, 46: 4281~4298（ESI高被引论文）
25.Huairong Zhang, Binxiao Li, Zhaomei Sun, Hong Zhou*,ShuSheng Zhang*
Integration ofintracellulartelomerasemonitoring by electrochemiluminescence technology and targeted cancer therapyby reactive oxygen species
Chem. Sci.,2017,8: 8025~8029
26.Yingshu Guo, Shuang Li, Yujie Wang,Shusheng Zhang*
Diagnosis-Therapy Integrative Systems based onMagnetic RNA Nanoflowersfor Co-drug Delivery andTargeted Therapy
Anal. Chem.,2017, 89(4): 2267~2274
27.Zhen Zhang,Yuting Jiao, Mengting Zhu,Shusheng Zhang*
Nuclear-Shell Biopolymers Initiated by Telomere Elongation for Individual Cancer Cell Imaging and Drug Delivery
Anal. Chem.,2017,89: 4320~4327
28.Lishang Liu, Congcong Wu,Shusheng Zhang*
Ultrasensitive detection of DNA and Ramos cell using In-Situ Selective Crystallization based Quartz Crystal Microbalance
Anal. Chem.,2017, 89(7): 4309~4313
29.Xinyue Song, Jiayu Zhang, Zihong Yue, Zonghua Wang, Zhihong Liu*,Shusheng Zhang*
Dual-activator codoped upconversion nanoprobe with core-multishell structure for in vitro and in vivo detection of hydroxyl radical
Anal. Chem.,2017, 89(20): 11021~11026
30.Yingshu Guo, Yujie Wang, Shuang Li, Li Niu, Di Wei,Shusheng Zhang*
DNA-spheres Decorated with Magnetic Nanocomposites Based on Terminal Transfer Reactions for Versatile Target Detection and Cellular Targeted Drug Delivery
Chem. Commun.,2017,53: 4826~4829
31.Pengfei Shi, Yuanchao Zhang, Zhaopeng Yu,ShuSheng Zhang*
Label-free Electrochemical Detection of ATP Based on Amino-functionalized Metal-organic Framework
Sci. Reports,2017, 7: 6500
32.王晓蒙，张振，刘静，张书圣*
复合纳米材料Cu2O@Au对水体中罗丹明B的检测应用研究
分许化学，2017, 45(12): 2026~2031
33.尚积祯，李志，郗冬梅*，张书圣*
生物纳米孔分析技术研究进展
应用化学，2017, 34 (8): 855~867
34.Zhen Zhang, Yuanyuan Wang, Ningbo Zhang,Shusheng Zhang*
Self-assembly of nucleic acid molecular aggregates catalyzed by a triple-helix probe for miRNA detection and single cell imaging
Chem. Sci.,2016,7: 4184~4189
35.Xiaoru Zhang, Ruijuan Li, Yuanyuan Chen,Shusheng Zhang*, Wenshuang Wang, Fuchuan Li*
Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method
Chem. Sci.,2016, 7: 6182~6189
36.Hong Zhou, Tongqian Han, Qin Wei*,Shusheng Zhang*
Efficient Enhancement of Electrochemiluminescence from Cadmium Sulfide Quantum Dots by Glucose Oxidase Mimicking Gold Nanoparticles for Highly Sensitive Assay of Methyltransferase Activity
Anal. Chem.,2016, 88(5): 2976~2983
37.Dongmei Xi, Jizhen Shang, Enguo Fan, Jinmao You, Shusheng Zhang*, Hua Wang*
Nanopore-Based Selective Discrimination of MicroRNAs with Single-Nucleotide Difference Using Locked Nucleic Acid-Modified Probes
Anal. Chem.,2016,88(21): 10540~10546
38.Jing Liu, Meirong Cui,Li Niu, Hong Zhou*,Shusheng Zhang*
Enhanced Peroxidase-like Properties of Graphene-hemin Composite decorated with Au Nanoflowers as Electrochemical Aptamer Biosensor for the detection of K562 Leukemia Cancer Cells
Chem.-Euro. J., 2016, 22 (50):17873（期刊VIP论文）
39.Sai Bi, Shuzhen Yue, Weiling Song,Shusheng Zhang*
A target-initiated DNA network caged on magnetic particles for amplified chemiluminescence resonance energy transfer imaging of microRNA and targeted drug delivery
Chem. Commun.,2016, 52(87): 12841~12844
40.Xiaoru Zhang, Y. Zhang, F. T. Chen, Y. Li, S. S. Zhang*, Visual Detection of Single-Nucleotide Polymorphisms and DNA Methyltransferase Based on cation-exchange of CuS nanoparticles and Click Chemistry of Functionalized Gold Nanoparticles,Chem. Commun., 2016,52: 13261~13264
41.Zhen Zhang, Yuting Jiao, Yuanyuan Wang,Shusheng Zhang*
Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
Sci. Reports,2016, 6: 29872
42.Jing Liu, Meirong Cui, Hong Zhou*,Shusheng Zhang*
Efficient double-quenching of electrochemiluminescence from CdS:Eu QDs by hemin-graphene-Au nanorods ternary composite for ultrasensitive immunoassay
Sci. Reports,2016, 6: 30577
43.Xiangjiang Zheng,Li Niu, Di Wei, Xuemei Li*,Shusheng Zhang*
Label-free detection of microRNA based on coupling multiple isothermal amplification techniques
Sci. Reports,2016, 6, 35982
44.Ting Song, Xilin Guo, Xuemei Li*,Shusheng Zhang*
Label-free electrochemical detection of RNA based on "Y" junction structure and restriction endonuclease-aided target recycling strategy
J. Electroanal. Chem.,2016, 781: 251-256
45.Meirong Cui, Ruizhen Yu, Xiaomeng Wang, Hong Zhou, Jing Liu*,Shusheng Zhang*
Novel graphene/Au-CdS:Eu composite-based electrochemiluminescence immunosensor for cancer biomarker detection by coupling resonance energy transfer and enzyme catalytic reaction
J. Electroanal. Chem.,2016, 781: 410~417
46.Hong Zhou, Jing Liu,Shusheng Zhang*
Quantum dots-based photoelectric conversion for biosensing applications
Trends Anal. Chem.,2015, 67: 56~73
47.Zhen Zhang, Yuanyuan Wang, Fuwei Zheng, Rui Ren,Shusheng Zhang*Ultrasensitive SERS Assay of Lysozyme using a Novel and Unique Four-Way Helical Junction Molecule probe for Signal Amplification
Chem. Commun.,2015, 51(5): 907~910
48.Jing Liu, Xiaoyan Xin, Hong Zhou,Shusheng Zhang*
Human serum biomarker detection based on a cascade signal amplification strategy by a DNA molecule machine
Chem. Commun.,2015, 51: 10843~10846
49.Xiaomeng Wang, Meirong Cui, Hong Zhou*,Shusheng Zhang*
DNA-Hybrid-Gated Functional Mesoporous Silica for Sensitive DNA Methyltransferase SERS Detection
Chem. Commun.,2015,51: 13983~19385
50.Jing Liu, Xiaoyan Xin, Hong Zhou,Shusheng Zhang*
A Ternary Composite based on Graphene, Hemin and Gold Nanorods with High Catalytic Activity for the Detection of Cell Surface Glycan Expression
Chem.-Euro. J.,2015, 21(5): 1908~1914（热点文章）
51.Xiaoru Zhang, Jiao Chen, Hongxia Liu,Shusheng Zhang*
Quartz crystal microbalance detection of protein amplified by nicked circling, rolling circle amplification and biocatalytic precipitation
Biosens. Bioelectron.,2015, 65: 341~345
52.Shusheng Zhang, Sai Bi, Xinyue Song
Nucleic Acid Amplification Strategies for Biosensing, Bioimaging, and Biomedicine,
Springer Nature, ISBN 978-981-13-7043-4（专著）
发明专利
1：一种用于靶向肺癌治疗的基因纳米探针及其制备方法和应用，ZL201810559188.1，李雪梅，袁丹丹，张家瑀，丁来荣，崔冰洁，张书圣*
2：一种适体和鲁米诺-金纳米粒子功能化的RNA膜及其制备方法和应用，ZL201711340992.2，郭英姝，尚鑫鑫，刘斐，张书圣*
3：一种多功能磁性DNA纳米球及其制备方法与应用，ZL201710116597.X，郭英姝，王玉洁，李 双，张书圣*
4：一种前列腺特异性抗原检测试剂与试剂盒，ZL201710622264.4，周宏;?刘静;?张宁波;?张书圣
5：一种基于鲁米诺功能化的磁性免疫探针检测甲胎蛋白的方法，ZL201510058853.5，李雪梅;?郭英姝;?张书圣
6：肿瘤早期高通量电化学发光检测方法的构建，ZL201410744007.4，周宏;刘静;?张宁波;?张书圣
7：一种新型人工模拟酶的合成及对糖基检测方法的构建，ZL201410744292.X，刘静;?周 宏;?张书圣
8：一种检测癌症标志物微小核糖核酸的试剂盒，ZL201410753668.3，张振;?王晓蒙;?张书圣
获奖情况：
1.2020，肿瘤标志物检测技术、装备及诊疗一体化研究，山东省自然科学二等奖，张书圣、毕赛、周宏、刘静、张怀荣
2.2015，基于信号放大的肿瘤标志物高灵敏检测技术研究，山东省自然科学二等奖，李雪梅、张晓茹、林洁华、张召香、张书圣
3.2014，肿瘤标志物的光电化学传感分析研究，教育部高等乐鱼平台资助大巴黎科学研究优秀成果奖自然科学类二等奖，张书圣、毕 赛、丁彩凤、接贵芬、张晓茹、郭英姝
4.2010，肿瘤标志物的生化分析检测技术及应用，山东省自然科学二等奖，张书圣、丁彩凤、李雪梅、林洁华、王卫
5.2010，化学学科研究生培养方案的改革与实践，山东省研究生教育教学成果三等奖 张书圣、匡少平、高洪涛、丁彩凤、王光信
6.2009，化工类专业化学系列课程教学改革与实践，山东省高等教育教学成果一等奖 张书圣、李明、匡少平、高洪涛、许泳吉、于跃芹
7.2008，糖苷功能配合物的合成、表征及其与DNA作用机理的电化学研究，山东省自然科学二等奖，张书圣、聂广明、李峰、牛叔妍、魏庆莉
8.2007，系列含氟液晶显示材料的合成及性能研究，山东省科技进步二等奖，张书圣、任 锐、宋修艳、李强、黄学青、董小红
邮箱：shushzhang@126.com
